Bisphenol S (BPS) - Cancer Science

What is Bisphenol S (BPS)?

Bisphenol S (BPS) is a chemical compound commonly used as a replacement for Bisphenol A (BPA) in various industrial applications. It is found in products such as thermal paper, plastics, and personal care items. Despite being considered a safer alternative to BPA, emerging research indicates that BPS may also pose significant health risks.

How does BPS relate to cancer?

BPS, like BPA, is an endocrine disruptor. Endocrine disruptors are chemicals that can interfere with hormone systems, potentially leading to carcinogenesis. Studies have shown that BPS can mimic the hormone estrogen and disrupt normal hormonal functions, which can contribute to the development and progression of certain types of cancer, such as breast and prostate cancer.

What studies have been conducted on BPS and cancer?

Several in vitro and animal studies have explored the impact of BPS on cancer. For instance, research has demonstrated that BPS can promote the proliferation of breast cancer cells. Additionally, studies on rodents have indicated that exposure to BPS can lead to increased rates of prostate cancer. Despite these findings, more comprehensive human studies are needed to fully understand the extent of BPS's impact on cancer risk.

Are there any regulatory measures on BPS?

Currently, regulatory measures on BPS vary by region. Some countries have started to review the safety profiles of BPS, but it is not as heavily regulated as BPA. For instance, the European Union has classified BPS as a substance of very high concern (SVHC) due to its potential health effects. In the United States, the FDA is conducting ongoing research to assess the risks associated with BPS exposure.

How can individuals reduce their exposure to BPS?

Reducing exposure to BPS involves adopting several precautionary measures. These include avoiding products made from polycarbonate plastics, minimizing the use of thermal paper receipts, and choosing BPS-free and BPA-free products. Reading labels and being cautious about the materials used in everyday items can also help limit exposure.

What are the future directions for research on BPS and cancer?

Future research will likely focus on long-term human studies to better understand the relationship between BPS exposure and cancer risk. Additionally, scientists are exploring safer alternatives to BPS and BPA that do not have endocrine-disrupting properties. Advancements in toxicology and molecular biology will play a crucial role in this ongoing research.

Relevant Publications

Determination of the urinary concentrations of six bisphenols in public servants by online solid-phase extraction-liquid chromatography tandem mass spectrometry.

Issue Release: 2024

Recent use of consumer and personal care products and exposures to select endocrine disrupting chemicals among urban children with asthma.

Issue Release: 2024

Conjugated Metabolites of Bisphenol A and Bisphenol S in Indoor Dust, Outdoor Dust, and Human Urine.

Issue Release: 2024

Removal of Bisphenol S (BPS) by Adsorption on Activated Carbons Commercialized in Brazil.

Issue Release: 2024

Degradation of the emerging brominated flame retardant tetrabromobisphenol S using organo-montmorillonite supported nanoscale zero-valent iron.

Issue Release: 2024

[Toxicity of bisphenol S on human normal ovarian epithelial cells mediated by ERβ-MAPK signaling pathway].

Issue Release: 2024

A combined in vitro-in silico method for assessing the androgenic activities of bisphenol A and its analogues.

Issue Release: 2024

Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations.

Issue Release: 2024

Halogenated bisphenol A derivatives potently inhibit human and rat 11β-hydroxysteroid dehydrogenase 1: Structure-activity relationship and molecular docking.

Issue Release: 2024

Chemical mixture that targets the epidermal growth factor pathway impairs human trophoblast cell functions.

Issue Release: 2024

Surface-surface contacted direct Z-scheme TiO-BiVO-PI heterostructure for enhanced photoelectrocatalytic degradation of bisphenols under solar driven.

Issue Release: 2024

Comparative cardiotoxicity assessment of bisphenol chemicals and estradiol using human induced pluripotent stem cell-derived cardiomyocytes.

Issue Release: 2024

Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis.

Issue Release: 2024

Occurrence of Chlorinated Derivatives of Bisphenol S in Paper Products and Their Potential Health Risks through Dermal Exposure.

Issue Release: 2024

Bisphenol A and its alternatives bisphenol S and F exposure with serum uric acid levels, hyperuricemia, and gout prevalence among US adults: a nationally representative cross-sectional study.

Issue Release: 2024

Cross sectional study on exposure to BPA and its analogues and semen parameters in Czech men.

Issue Release: 2024

Developmental exposure to Bisphenol F and Bisphenol S induces autism-like endophenotypes in adult Drosophila melanogaster.

Issue Release: 2024

Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohort.

Issue Release: 2024

Enhancing the efficient degradation of BPS using the BPNS-CdS composite catalyst under visible light.

Issue Release: 2024

Effects of Behavioral, Clinical, and Policy Interventions in Reducing Human Exposure to Bisphenols and Phthalates: A Scoping Review.

Issue Release: 2024

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