Fallopian Tube cancer - Cancer Science

What is Fallopian Tube Cancer?

Fallopian tube cancer is a rare type of cancer that originates in the fallopian tubes, which connect the ovaries to the uterus. This type of cancer is less common compared to other forms of gynecologic cancers such as ovarian cancer or endometrial cancer.

What are the Risk Factors?

Several risk factors can increase the likelihood of developing fallopian tube cancer. These include genetic mutations such as BRCA1 and BRCA2, a family history of ovarian or breast cancer, and certain reproductive history factors. Women who have never been pregnant or who have had their first child after the age of 35 may have a higher risk.

What are the Symptoms?

The symptoms of fallopian tube cancer can often be vague and non-specific. Common symptoms include abnormal vaginal bleeding, pelvic pain, and a pelvic mass. Some women may also experience abdominal discomfort or bloating. Due to the non-specific nature of these symptoms, fallopian tube cancer is often diagnosed at a later stage.

How is it Diagnosed?

The diagnosis of fallopian tube cancer typically involves a combination of pelvic examinations, imaging studies (such as ultrasound or CT scans), and blood tests to measure tumor markers like CA-125. A definitive diagnosis is usually made through a biopsy, where a sample of tissue is examined under a microscope.

What are the Treatment Options?

Treatment for fallopian tube cancer usually involves a combination of surgery and chemotherapy. Surgery aims to remove as much of the cancer as possible and may include a hysterectomy, removal of the ovaries and fallopian tubes, and sometimes removal of nearby lymph nodes. Chemotherapy is often used to kill any remaining cancer cells and reduce the risk of recurrence.

What is the Prognosis?

The prognosis for fallopian tube cancer depends on several factors, including the stage of the cancer at diagnosis, the patient’s overall health, and how well the cancer responds to treatment. Early-stage cancers have a better prognosis compared to those diagnosed at a later stage.

Prevention and Screening

There are no specific screening tests for fallopian tube cancer, making prevention challenging. However, women with a high risk due to genetic mutations may consider preventive measures such as prophylactic removal of the fallopian tubes and ovaries. Regular gynecological exams and awareness of symptoms can also aid in early detection.

Research and Advances

Ongoing research is focused on understanding the genetic and molecular basis of fallopian tube cancer, which may lead to more effective treatments. Advances in targeted therapies and immunotherapy are also being explored as potential options for treating this rare cancer.

Relevant Publications

Misdiagnosis of a Drain-site Hernia Containing Fallopian Tube Fimbria on F-FDG PET/CT.

Issue Release: 2024

Predictors of olaparib discontinuation owing to adverse drug events in patients with ovarian, peritoneal, or fallopian tube cancer: a retrospective observational study.

Issue Release: 2024

The first real-world study on the role of carbon ion radiotherapy for oligo-metastatic, persistent, or recurrent (MPR) ovarian/fallopian tube cancer.

Issue Release: 2024

Robotic HIPEC with use of a vaginal GelPoint®.

Issue Release: 2024

Preclinical evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer.

Issue Release: 2024

A phase I study of Mirvetuximab Soravtansine and gemcitabine in patients with FRα-positive recurrent ovarian, primary peritoneal, fallopian tube, or endometrial cancer, or triple negative breast cancer.

Issue Release: 2024

An international worldwide retrospective cohort observational study comparing primary cytoreductive surgery with neoadjuvant chemotherapy and interval cytoreductive surgery in patients with carcinoma of the ovary, fallopian tubes, and peritoneum (SUROVA trial).

Issue Release: 2024

Salpingectomy for ovarian cancer prevention: Video education for the surgeon.

Issue Release: 2024

Clinical outcomes following identification of an incidental p53 signature in the fallopian tube.

Issue Release: 2024

Prevalence and spectrum of germline BRCA1 and BRCA2 in a cohort of ovarian cancer patients from the Salento peninsula (Southern Italy): a matter of preventive health.

Issue Release: 2024

Genomic Catastrophe (Chromothripsis and Polyploidy) Correlates With Tumor Distribution in Extrauterine High-grade Serous Carcinoma.

Issue Release: 2024

The karyometric signature is altered in fallopian tubes with serous tubal intraepithelial carcinoma.

Issue Release: 2024

Has time to chemotherapy from primary debulking surgery in advanced ovarian cancer an impact on survival? - A population-based nationwide SweGCG study.

Issue Release: 2024

Global epidemiology of epithelial ovarian cancer.

Issue Release: 2024

Rates of paclitaxel hypersensitivity reactions using a modified Markman\'s infusion protocol as primary prophylaxis.

Issue Release: 2024

The impact of Paclitaxel-based hyperthermic intraperitoneal chemotherapy in advanced high-grade serous ovarian cancer patients - interim analysis of safety and immediate efficacy of a randomized control trial (C-HOC trial).

Issue Release: 2024

Fallopian tube cancer with inguinal lymph node metastasis as the first symptom: A case study and review of the literature.

Issue Release: 2024

Impact of gated FDG PET/CT on the staging of patients with suspected or proven newly diagnosed advanced epithelial ovarian, fallopian tube, and primary peritoneal cancer: results from a non-randomized, phase II clinical trial.

Issue Release: 2024

Human papillomavirus infection of the fallopian tube as a potential risk factor for epithelial ovarian cancer.

Issue Release: 2024

Diagnosis Shift in Site of Origin of Tubo-Ovarian Carcinoma.

Issue Release: 2024

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