National Human Genome Research Institute - Cancer Science

What is the National Human Genome Research Institute (NHGRI)?

The National Human Genome Research Institute (NHGRI) is a division of the National Institutes of Health (NIH) that focuses on understanding the genome's role in health and disease. Established in 1989, NHGRI has been at the forefront of genome research, contributing significantly to the Human Genome Project and continuing to advance genomic science.

How does NHGRI contribute to Cancer research?

NHGRI supports cancer research through funding, resources, and collaboration. By studying the genetic mutations that cause cancer, NHGRI aims to develop targeted therapies and improve early detection methods. Their research encompasses various types of cancer, including breast, colon, and lung cancer, focusing on understanding the complex genetic changes that drive these diseases.

What are some key initiatives by NHGRI in Cancer research?

One of the pivotal initiatives by NHGRI is the Cancer Genome Atlas (TCGA), a comprehensive project that maps the genetic changes in different cancer types. Another significant program is the Clinical Sequencing Evidence-Generating Research (CSER)

Relevant Publications

Beyond Meta-Omics: Functional Genomics in Future Marine Microbiome Research.

Issue Release: 2024

Advancing genomics to improve health equity.

Issue Release: 2024

Genome Sequencing for Diagnosing Rare Diseases.

Issue Release: 2024

Identification of bacterial determinants of tuberculosis infection and treatment outcomes: a phenogenomic analysis of clinical strains.

Issue Release: 2024

Tracing the origin of SARS-CoV-2 omicron-like spike sequences detected in an urban sewershed: a targeted, longitudinal surveillance study of a cryptic wastewater lineage.

Issue Release: 2024

Causal effect of gut microbiota on pancreatic cancer: A Mendelian randomization and colocalization study.

Issue Release: 2024

An inverse causal relationship between serum 25-hydroxyvitamin D levels and pulmonary hypertension: A two-sample Mendelian randomization study.

Issue Release: 2024

STING signalling compensates for low tumour mutation burden to drive anti-tumour immunity.

Issue Release: 2024

Increased risk of kidney failure in patients with genetic kidney disorders.

Issue Release: 2024

Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.

Issue Release: 2024

Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations.

Issue Release: 2024

Genomic characterization of human respiratory syncytial virus circulating in Islamabad, Pakistan, during an outbreak in 2022-2023.

Issue Release: 2024

Genomic characterization of human respiratory syncytial virus circulating in Islamabad, Pakistan, during an outbreak in 2022-2023.

Issue Release: 2024

The impact of ovarian stimulation on the human endometrial microenvironment.

Issue Release: 2024

Understanding the Gap: A Cross-Sectional Survey of ELSI Scholars\' Dissemination Practices and Translation Goals.

Issue Release: 2024

Semi-supervised machine learning method for predicting homogeneous ancestry groups to assess Hardy-Weinberg equilibrium in diverse whole-genome sequencing studies.

Issue Release: 2024

Ethical, Legal, and Social Implications of Gene-Environment Interaction Research.

Issue Release: 2024

Evaluation of the feasibility, diagnostic yield, and clinical utility of rapid genome sequencing in infantile epilepsy (Gene-STEPS): an international, multicentre, pilot cohort study.

Issue Release: 2023

Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting: the RV217 acute infection cohort study.

Issue Release: 2023

Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges.

Issue Release: 2023

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