Patient Derived Xenografts (pdxs) - Cancer Science

Relevant Publications

Dual inhibition of the TrkA and JAK2 pathways using entrectinib and pacritinib suppresses the growth and metastasis of HER2-positive and triple-negative breast cancers.

Issue Release: 2024

HPV16 genome structure analysis in oropharyngeal cancer PDXs identifies tumors with integrated and episomal genomes.

Issue Release: 2024

Lestaurtinib\'s antineoplastic activity converges on JAK/STAT signaling to inhibit advanced forms of therapy resistant ovarian cancer.

Issue Release: 2024

PD-L1 has a heterogeneous and dynamic expression in gastric cancer with implications for immunoPET.

Issue Release: 2024

PDX Models in Theranostic Applications: Generation and Screening for B Cell Lymphoma of Human Origin.

Issue Release: 2024

Bystander effects, pharmacokinetics, and linker-payload stability of EGFR-targeting antibody-drug conjugates Losatuxizumab vedotin and Depatux-M in glioblastoma models.

Issue Release: 2024

PKMYT1 is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer.

Issue Release: 2024

Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma.

Issue Release: 2024

Targeting TREX1 induces innate immune response in drug-resistant Small Cell Lung Cancer.

Issue Release: 2024

Development and characterisation of [F]TTDP, a novel T cell immunoglobulin and ITIM domain tracer, in humanised mice and non-human primates.

Issue Release: 2024

Fibroblast growth factor receptor 1 inhibition suppresses pancreatic cancer chemoresistance and chemotherapy-driven aggressiveness.

Issue Release: 2024

Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer.

Issue Release: 2024

Quercetin-induced degradation of RhoC suppresses hepatocellular carcinoma invasion and metastasis.

Issue Release: 2024

Biological and targeting differences between the rare KRAS A146T and canonical KRAS mutants in gastric cancer models.

Issue Release: 2024

Co-targeting CD47 and VEGF elicited potent anti-tumor effects in gastric cancer.

Issue Release: 2024

Preclinical models for bladder cancer therapy research.

Issue Release: 2024

A risk-reward examination of sample multiplexing reagents for single cell RNA-Seq.

Issue Release: 2024

Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-omics Approach Using Patient-Derived Xenografts.

Issue Release: 2024

Empowering personalized medicine: unleashing the potential of patient-derived explants in clinical practice.

Issue Release: 2024

Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges.

Issue Release: 2024

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