Subungual Melanoma - Cancer Science

What is Subungual Melanoma?

Subungual melanoma is a rare form of melanoma that occurs under the nail, commonly affecting the thumb or big toe. It represents about 0.7% to 3.5% of all melanoma cases. This type of melanoma is often mistaken for less severe conditions, leading to delayed diagnosis and treatment.

What Causes Subungual Melanoma?

The exact cause of subungual melanoma is not fully understood. Unlike most other types of melanoma, subungual melanoma is not typically linked to UV radiation exposure. Genetic factors and previous trauma to the nail may play a role in its development.

What are the Symptoms?

Recognizing subungual melanoma can be challenging due to its subtle symptoms. Common signs include:
A dark streak or band under the nail, which often increases in size over time
Nail splitting or cracking
Nail lifting from the nail bed
Bleeding or drainage under the nail
Pigment spreading to the surrounding skin
These symptoms can be mistaken for fungal infections or other benign nail conditions, so it is crucial to consult a healthcare provider for an accurate diagnosis.

How is Subungual Melanoma Diagnosed?

Diagnosis involves a thorough clinical examination and may require a biopsy of the nail and surrounding tissues. Dermoscopy, a non-invasive imaging technique, can also be used to examine the nail bed. Early diagnosis is essential for effective treatment.

What are the Treatment Options?

Treatment for subungual melanoma typically involves surgical removal of the affected nail and underlying tissue. In more advanced cases, partial or complete amputation of the digit may be necessary. Other treatment options include:
The choice of treatment depends on the stage of the melanoma and other individual factors.

What is the Prognosis?

The prognosis for subungual melanoma varies based on the stage at diagnosis. Early-stage melanomas that have not spread beyond the nail bed have a relatively good prognosis. However, advanced cases where the melanoma has spread to other parts of the body have a poorer outlook. Regular follow-ups and monitoring are crucial for managing the disease.

How Can Subungual Melanoma be Prevented?

While there is no guaranteed way to prevent subungual melanoma, early detection is key to improving outcomes. Pay attention to any changes in your nails and seek medical advice if you notice any unusual signs. Regular skin and nail examinations by a healthcare provider can help in early detection.

Conclusion

Subungual melanoma is a rare but serious form of melanoma that requires prompt diagnosis and treatment. Awareness of its symptoms and risk factors can aid in early detection, which is crucial for better treatment outcomes. If you notice any changes in your nails, consult a healthcare provider immediately.



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