What are the Clinical Implications of Aerobic Glycolysis in Cancer?
Aerobic glycolysis has several clinical implications. It can serve as a diagnostic marker, as increased glucose uptake by tumors is detectable using positron emission tomography (PET) scans. Targeting glycolysis with specific inhibitors, such as 2-deoxy-D-glucose and lactate dehydrogenase inhibitors, offers potential therapeutic strategies. Moreover, understanding this metabolic shift provides insights into cancer cell chemoresistance and the development of novel treatment approaches.
