platelet derived growth factor receptor (pdgfr)

What are the Therapeutic Implications of Targeting PDGFR?

Given the role of PDGFR in various cancers, it has become a significant therapeutic target. Tyrosine kinase inhibitors (TKIs) like imatinib, sunitinib, and pazopanib have been developed to inhibit PDGFR signaling. These inhibitors have shown efficacy in treating PDGFR-driven cancers such as GISTs and certain leukemias. However, resistance to TKIs can develop, often due to secondary mutations in the PDGFR gene, necessitating the development of next-generation inhibitors.

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