The American Association for Cancer Research (AACR) Project GENIE (Genomics Evidence Neoplasia Information Exchange) is a high-impact initiative designed to power precision medicine in oncology. It is an international, multi-institutional consortium focused on leveraging cancer genomics data to improve clinical decision-making and accelerate cancer research. By aggregating and harmonizing clinical-grade sequencing data from leading cancer centers, AACR Project GENIE provides a robust resource for researchers and clinicians seeking to understand the genetic underpinnings of cancer.