The 4Kscore test is a blood test that helps predict the risk of aggressive prostate cancer. It is designed to aid in the decision-making process regarding whether to proceed with a prostate biopsy. This test measures four different biomarkers: Total PSA, Free PSA, Intact PSA, and Human Kallikrein 2 (hK2), along with patient clinical information like age, prior biopsy history, and Digital Rectal Exam (DRE) status.