What Role Do Bcl-2 Family Proteins Play in Cancer?
Dysregulation of Bcl-2 family proteins is a common feature in various cancers. Overexpression of anti-apoptotic proteins like Bcl-2 and Bcl-xL can lead to increased cell survival, making cancer cells resistant to apoptosis. This resistance to cell death allows for the uncontrolled proliferation of cancer cells, contributing to tumor growth and metastasis.