cervix - Cancer Science

What is Cervical Cancer?

Cervical cancer is a type of cancer that begins in the cells of the cervix, the lower part of the uterus that connects to the vagina. It is primarily caused by persistent infection with certain strains of the Human Papillomavirus (HPV), a common sexually transmitted infection.

How Common is Cervical Cancer?

Cervical cancer is the fourth most common cancer in women worldwide. In 2020, there were an estimated 604,000 new cases and 342,000 deaths globally. It is more prevalent in low- and middle-income countries due to limited access to screening and vaccination programs.

What are the Risk Factors?

The primary risk factor for cervical cancer is infection with high-risk HPV types. Other risk factors include:
Early sexual activity
Multiple sexual partners
Smoking
Immunosuppression
Long-term use of oral contraceptives
Having many children

What are the Symptoms?

Early stages of cervical cancer often have no symptoms. As the cancer progresses, symptoms may include:
Abnormal vaginal bleeding (e.g., after intercourse, between periods, postmenopausal)
Unusual vaginal discharge
Pelvic pain
Pain during intercourse

How is Cervical Cancer Diagnosed?

Diagnosis typically involves a combination of:
Pap smear tests to detect precancerous or cancerous cells
HPV testing for high-risk virus strains
Colposcopy to closely examine the cervix and take biopsies if necessary
Biopsy to confirm diagnosis and determine the stage of cancer

What are the Stages of Cervical Cancer?

Cervical cancer is staged from I to IV, based on the extent of the tumor:
Stage I: Cancer is confined to the cervix
Stage II: Cancer has spread beyond the cervix but not to the pelvic wall or lower third of the vagina
Stage III: Cancer has spread to the lower third of the vagina or pelvic wall, potentially causing kidney problems
Stage IV: Cancer has spread to nearby organs or distant parts of the body

What are the Treatment Options?

Treatment depends on the stage of the cancer and may include:
Surgery (e.g., hysterectomy, removal of nearby lymph nodes)
Radiation therapy to destroy cancer cells
Chemotherapy to kill cancer cells or enhance the effects of radiation therapy
Targeted therapy for advanced cases

How Can Cervical Cancer be Prevented?

Prevention strategies include:
HPV vaccination for girls and boys before they become sexually active
Regular screening with Pap smears and HPV testing
Safe sexual practices, including the use of condoms
Quitting smoking

What is the Prognosis?

The prognosis for cervical cancer largely depends on the stage at diagnosis. Early-stage cervical cancer has a high survival rate, especially when detected through regular screening. Advanced-stage cervical cancer has a lower survival rate, emphasizing the importance of preventive measures and early detection.



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