Inhibition Of Compensatory Pathways - Cancer Science

Relevant Publications

Glypican-3 deficiency in liver cancer upregulates MAPK/ERK pathway but decreases cell proliferation.

Issue Release: 2024

Triple Blockade of Oncogenic RAS Signaling Using KRAS and MEK Inhibitors in Combination with Irradiation in Pancreatic Cancer.

Issue Release: 2024

Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia.

Issue Release: 2024

Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila.

Issue Release: 2024

PRMT5 orchestrates EGFR and AKT networks to activate NFκB and promote EMT.

Issue Release: 2024

Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRAS-mutant pancreatic ductal adenocarcinoma.

Issue Release: 2024

Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition.

Issue Release: 2024

Chronic Epinephrine-Induced Endoplasmic Reticulum and Oxidative Stress Impairs Pancreatic β-Cells Function and Fate.

Issue Release: 2024

Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS-mutant Cancers.

Issue Release: 2024

Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation.

Issue Release: 2024

Mechanisms of resistance to venetoclax in hematologic malignancies.

Issue Release: 2024

Effects of substrate availability and mitochondrial disruption on oxidative metabolism and sperm motility in fertile dogs.

Issue Release: 2024

Synaptotagmin 4 supports spontaneous axon sprouting after spinal cord injury.

Issue Release: 2024

Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network.

Issue Release: 2024

Regulators of rDNA array morphology in fission yeast.

Issue Release: 2024

FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma.

Issue Release: 2024

Combined inhibition of RAD51 and CHK1 causes synergistic toxicity in cisplatin resistant cancer cells by triggering replication fork collapse.

Issue Release: 2024

MAPK-negative feedback regulation confers dependence to JAK2 signaling.

Issue Release: 2023

Metabolic control analysis of the transsulfuration pathway and the compensatory role of the cysteine transport in Trypanosoma cruzi.

Issue Release: 2023

RapaLink-1 outperforms rapamycin in alleviating allogeneic graft rejection by inhibiting the mTORC1-4E-BP1 pathway in mice.

Issue Release: 2023

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