Kinesin Spindle Protein (ksp) - Cancer Science

Relevant Publications

Coupling Kinesin Spindle Protein and Aurora B Inhibition with Apoptosis Induction Enhances Oral Cancer Cell Killing.

Issue Release: 2024

Discovery of novel KSP-targeting PROTACs with potent antitumor effects in vitro and in vivo.

Issue Release: 2024

The Application of Kinesin Inhibitors in Medical Issues.

Issue Release: 2024

Development of Half-Sandwich Ru, Os, Rh, and Ir Complexes Bearing the Pyridine-2-ylmethanimine Bidentate Ligand Derived from 7-Chloroquinazolin-4(3H)-one with Enhanced Antiproliferative Activity.

Issue Release: 2024

Design, Synthesis and Evaluation of Biological Activity of Ferrocene-Ispinesib Hybrids - Impact of a Ferrocenyl Group on the Antiproliferative and KSP Inhibitory Activity.

Issue Release: 2023

A novel antibody-KSP inhibitor conjugate improves KSP inhibitor efficacy in vitro and in vivo.

Issue Release: 2023

Organometallic Ru, Os, Rh and Ir half-sandwich conjugates of ispinesib - impact of the organometallic group on the antimitotic activity.

Issue Release: 2023

Antibody-drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties.

Issue Release: 2022

The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma.

Issue Release: 2022

Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates.

Issue Release: 2022

Role of KSP Inhibitors as Anti-cancer Therapeutics: An Update.

Issue Release: 2022

Kinesin spindle protein inhibitor exacerbates cisplatin-induced hair cell damage.

Issue Release: 2022

Design, synthesis, and evaluation of a novel prodrug, a S-trityl--cysteine derivative targeting kinesin spindle protein.

Issue Release: 2021

Systemic delivery of CRISPR/Cas9 to hepatic tumors for cancer treatment using altered tropism of lentiviral vector.

Issue Release: 2021

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components.

Issue Release: 2020

Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands.

Issue Release: 2020

Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer.

Issue Release: 2020

KSP siRNA/paclitaxel-loaded PEGylated cationic liposomes for overcoming resistance to KSP inhibitors: Synergistic antitumor effects in drug-resistant ovarian cancer.

Issue Release: 2020

Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma.

Issue Release: 2020

Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles.

Issue Release: 2019

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