Polo Like Kinase 1 (plk1) - Cancer Science

Relevant Publications

The Role of Polo-Like Kinase 1 (PLK1) O-GlcNAcylation in Mitosis.

Issue Release: 2025

Time-Lapse Imaging to Analyze Cell Fate in Response to Antimitotics.

Issue Release: 2025

A phosphate-binding pocket in cyclin B3 is essential for XErp1/Emi2 degradation in meiosis I.

Issue Release: 2025

Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD.

Issue Release: 2024

Application of PLK1 and HOXA13 Gene Expression Levels in Urine in the Diagnosis of Non-muscle Invasive Bladder Cancer.

Issue Release: 2024

PLK1 inhibition leads to mitotic arrest and triggers apoptosis in cholangiocarcinoma cells.

Issue Release: 2024

CENP-C-targeted PLK-1 regulates kinetochore function in C. elegans embryos.

Issue Release: 2024

Dual TTK/PLK1 inhibition has potent anticancer activity in TNBC as monotherapy and in combination.

Issue Release: 2024

Dissecting the Multiple Functions of the Polo-Like Kinase 1 in the C. elegans Zygote.

Issue Release: 2024

O-GlcNAcylation stimulates the deubiquitination activity of USP16 and regulates cell cycle progression.

Issue Release: 2024

Proteasome activation is critical for cell death induced by inhibitors of polo-like kinase 1 (PLK1) in multiple cancers.

Issue Release: 2024

Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma.

Issue Release: 2024

Concurrent targeting of GSK3 and MEK as a therapeutic strategy to treat pancreatic ductal adenocarcinoma.

Issue Release: 2024

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton.

Issue Release: 2024

Polo-like kinase 1 inhibition modulates urinary tract smooth muscle contraction and bladder cell transcriptional programs.

Issue Release: 2024

Polo-like Kinase 1 Predicts Lymph Node Metastasis in Middle Eastern Colorectal Cancer Patients; Its Inhibition Reverses 5-Fu Resistance in Colorectal Cancer Cells.

Issue Release: 2024

NOD2 reduces the chemoresistance of melanoma by inhibiting the TYMS/PLK1 signaling axis.

Issue Release: 2024

Novel insights into the circadian modulation of lipid metabolism in chicken livers revealed by RNA sequencing and weighted gene co-expression network analysis.

Issue Release: 2024

Exploiting the chemical diversity space of phosphopeptide binding to nasopharyngeal carcinoma PLK1 PBD domain with unnatural amino acid building blocks by using QSAR-based genetic optimization.

Issue Release: 2024

PLK1 overexpression suppresses homologous recombination and confers cellular sensitivity to PARP inhibition.

Issue Release: 2024

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