Sulfonamide Derivatives - Cancer Science

What Are Sulfonamide Derivatives?

Sulfonamide derivatives are a class of compounds characterized by the presence of the sulfonamide group, which consists of a sulfonyl functional group attached to an amine. These compounds have shown significant potential in various therapeutic areas, including cancer treatment.

How Do Sulfonamide Derivatives Work in Cancer Treatment?

Sulfonamide derivatives exhibit anti-cancer properties through multiple mechanisms. They can inhibit enzymes involved in cell proliferation, disrupt cell signaling pathways, and induce cell cycle arrest and apoptosis. Some derivatives also target angiogenesis, the process by which new blood vessels form, which is crucial for tumor growth and metastasis.

What Are Some Prominent Sulfonamide-Based Anti-Cancer Drugs?

One of the most well-known sulfonamide-based drugs is sulfasalazine, initially developed for rheumatoid arthritis but later found to have anti-cancer properties. Another example is E7070 (Indisulam), which has been investigated for its ability to inhibit cell cycle regulators and has shown promise in clinical trials for various cancers.

What Types of Cancer Are Targeted by Sulfonamide Derivatives?

Sulfonamide derivatives have been studied for their efficacy against a wide range of cancers, including breast cancer, lung cancer, colorectal cancer, and leukemia. Their versatility in targeting multiple pathways makes them valuable candidates for treating different cancer types.

What Are the Challenges in Using Sulfonamide Derivatives for Cancer Treatment?

Despite their potential, sulfonamide derivatives face several challenges. These include drug resistance, off-target effects, and toxicity. Researchers are actively working on modifying these derivatives to enhance their specificity and reduce side effects, thus improving their therapeutic index.

How Are New Sulfonamide Derivatives Developed?

The development of new sulfonamide derivatives involves structure-activity relationship (SAR) studies, which help in understanding how structural modifications influence biological activity. Advanced techniques such as computational modeling and high-throughput screening are employed to identify promising candidates. Subsequent preclinical and clinical trials are conducted to evaluate their safety and efficacy.

What Is the Future of Sulfonamide Derivatives in Cancer Treatment?

The future of sulfonamide derivatives in cancer treatment looks promising, with ongoing research focusing on multi-targeted therapies and combination treatments. By combining sulfonamide derivatives with other therapeutic agents, it is possible to enhance their efficacy and overcome resistance mechanisms, paving the way for more effective cancer treatments.

Relevant Publications

Design and synthesis of sulfonamide phenothiazine derivatives as novel ferroptosis inhibitors and their therapeutic effects in spinal cord injury.

Issue Release: 2024

Unveiling the promise of pyrimidine-modified CDK inhibitors in cancer treatment.

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Discovery of new cyclopropane sulfonamide derivatives as EGFR inhibitors to overcome C797S-mediated resistance and EGFR double mutation.

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Unveiling sultam in drug discovery: spotlight on the underexplored scaffold.

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Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents.

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Synthesis and Characterization of Sulfonamide-Containing Naphthalimides as Fluorescent Probes.

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New biologically active sulfonamides as potential drugs for Alzheimer\'s disease.

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Elucidating the Anticancer Mechanisms of Cinnamoyl Sulfonamide Hydroxamate: Insights From DNA Content Analysis and Gene Expression Profiling in Squamous Cell Carcinoma.

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Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis.

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Sulfonamide modified chitosan oligosaccharide with high nematicidal activity against Meloidogyne incognita.

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Sulfonamides as anticancer agents: A brief review on sulfonamide derivatives as inhibitors of various proteins overexpressed in cancer.

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Cu-Amidobis(phosphine)-Catalyzed Direct Amidation of Unactivated Alkanes via C(sp)-H Activation.

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Phthalazine sulfonamide derivatives as carbonic anhydrase inhibitors. Synthesis, biological and in silico evaluation.

Issue Release: 2024

Discovery and structure-activity relationship of dimesulfazet: a novel rice paddy herbicide.

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A combined ligand-based and structure-based molecular modeling approach to pinpoint the key structural attributes of hydroxamate derivatives as promising meprin β inhibitors.

Issue Release: 2024

New PFASs Identified in AFFF Impacted Groundwater by Passive Sampling and Nontarget Analysis.

Issue Release: 2024

Discovery of water-soluble semicarbazide-containing sulfonamide derivatives possessing favorable anti-glaucoma effect and drug-like properties.

Issue Release: 2024

1,3-Diaryl Triazenes Incorporating Disulfonamides Show Both Antiproliferative Activity and Effective Inhibition of Tumor-associated Carbonic Anhydrases IX and XII.

Issue Release: 2024

Thiosemicarbazone-benzene Sulfonamide Derivatives as Human Carbonic Anhydrases Inhibitors: Synthesis, Characterization, and In silico Studies.

Issue Release: 2024

Discovery of 2,4-diarylaminopyrimidine derivatives bearing sulfonamide moiety as novel FAK inhibitors.

Issue Release: 2024

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