Stuart. H. Orkin - Cancer Science

Author Information

Stuart H. Orkin is affiliated with the Division of Hematology/Oncology at Boston Children's Hospital and the Department of Pediatric Oncology at the Dana-Farber Cancer Institute (DFCI). He is also associated with the Harvard Stem Cell Institute and Harvard Medical School in Boston, MA. Additionally, he is a part of the Howard Hughes Medical Institute in Boston, MA. His research primarily focuses on hematopoiesis and leukemia.

Research Contributions

Stuart H. Orkin has made significant contributions to the field of cancer research, specifically in the areas of hematopoiesis and leukemia. His recent work includes exploring strategies to induce cell-intrinsic inflammation to target AML blasts, understanding the developmental maturation of the hematopoietic system through various molecular axes, and investigating the regulatory modules in KMT2A-rearranged leukemia. His research also covers genomic analysis related to the hunger-suppressing effects of leptin and the dietary effects on intestinal tumorigenesis. His prolific output includes studies on super-enhancers during cell differentiation and the molecular mechanisms involving master transcription factors in congenital anemia.

Aliases

Stuart H. Orkin is also known by several aliases, including S. H. Orkin, Stuart H Orkin, Stuart. H. Orkin, Stuart Orkin, S. Orkin, S Orkin, and S H Orkin.

Publication and Citation Metrics

Metric	Value
Citation Count	86,260
h-index	160
Paper Count	760

Publications:

Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts.

DOI: 10.1158/2159-8290.CD-21-0956

Year: 2022

Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis

DOI: 10.1016/j.celrep.2022.110587

Year: 2022

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

DOI: 10.1101/gad.349284.121

Year: 2022

Haig H. Kazazian, Jr. (1937–2022)

DOI: 10.1101/gr.276712.122

Year: 2022

Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin’s hunger-suppressing effects

DOI: 10.1101/2022.01.03.474708

Year: 2022

Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-PRC1 axis

DOI: 10.1101/2022.01.05.474696

Year: 2022

A Congenital Anemia Reveals Distinct Targeting Mechanisms for Master Transcription Factor GATA1.

DOI: 10.1182/blood.2021013753

Year: 2022

Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.

DOI: 10.1016/j.stem.2021.08.007

Year: 2021

Lin28b-Let-7-PRC1 Axis Guides Developmental Maturation of the Hematopoietic System

DOI: 10.1182/blood-2021-146004

Year: 2021

Mapping the evolving landscape of super-enhancers during cell differentiation

DOI: 10.1186/s13059-021-02485-x

Year: 2021

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