HULC contributes to cancer progression through multiple mechanisms:
Regulation of Gene Expression: HULC can modulate the expression of various oncogenes and tumor suppressor genes, thereby influencing cell proliferation, apoptosis, and metastasis. Interaction with MicroRNAs: HULC can act as a molecular sponge for certain microRNAs, thereby preventing them from binding to their target mRNAs. This can lead to the upregulation of oncogenes. Epigenetic Modifications: HULC can influence epigenetic modifications such as DNA methylation and histone modification, which are critical for gene regulation in cancer cells.
