How do lipids, proteins, and DNA interact in cancer?
The interaction between lipids, proteins, and DNA is complex and integral to cancer development. Lipid-modifying enzymes can influence the activity of proteins involved in cell signaling and DNA repair. For instance, lipid rafts in the cell membrane can compartmentalize and regulate signaling proteins that control cell growth and survival. Mutated proteins can result in aberrant signaling pathways that lead to DNA damage and further genetic mutations. Additionally, lipid signaling molecules like prostaglandins can influence gene expression by interacting with nuclear receptors, thereby affecting DNA transcription and contributing to tumor growth.
