Are There Therapeutic Strategies to Target Hypoxia?
Several therapeutic strategies are being developed to target hypoxia in cancer. These include the use of hypoxia-activated prodrugs that become cytotoxic only under low oxygen conditions, thereby specifically targeting hypoxic cancer cells. Another approach involves inhibiting HIFs to disrupt the adaptive responses of cancer cells to hypoxia. Additionally, therapies that normalize tumor vasculature and improve oxygen delivery are being explored to enhance the efficacy of conventional treatments.
