While not all cases of colon cancer can be prevented, certain measures can significantly reduce risk. Regular screening is crucial, especially for those over 50 or with a family history of the disease. Lifestyle modifications such as maintaining a healthy diet rich in fruits, vegetables, and whole grains, regular exercise, and avoiding smoking and excessive alcohol can also help. Some research suggests that aspirin or other anti-inflammatory drugs may lower risk, but these should only be taken under medical advice.