Can Direct Repair Mechanisms be Targeted in Cancer Therapy?
Given the role of direct repair in mediating resistance to chemotherapy, researchers are exploring ways to inhibit these repair mechanisms to enhance the efficacy of cancer treatments. For instance, inhibitors of MGMT are being developed to sensitize tumors to alkylating agents. Additionally, understanding the interplay between direct repair and other DNA repair pathways could lead to novel therapeutic strategies that exploit synthetic lethality.
