While it is challenging to prevent drug resistance entirely, several strategies can be employed to delay its onset:
Combination therapy: Using multiple drugs with different mechanisms of action can reduce the likelihood of resistance. Sequential therapy: Alternating drugs or treatment regimens can prevent cancer cells from adapting to a single agent. Dose optimization: Adjusting drug dosages and schedules can help maximize efficacy while minimizing resistance. Targeting the microenvironment: Therapies aimed at modifying the tumor microenvironment can enhance drug sensitivity.
