Researchers are actively exploring various strategies to overcome MDR:
Inhibitors of Efflux Pumps: Drugs like verapamil and cyclosporine can inhibit the function of efflux pumps, increasing the intracellular concentration of chemotherapeutic agents. Nanoparticle Drug Delivery: Encapsulating drugs in nanoparticles can enhance their delivery to cancer cells and reduce the impact of efflux pumps. Combination Therapy: Using a combination of drugs with different mechanisms of action can reduce the likelihood of resistance development. Gene Therapy: Approaches that target the genes responsible for drug resistance are being investigated. Targeted Therapies: Drugs that specifically target cancer cell markers or pathways involved in resistance can be more effective than traditional chemotherapy.
