Can Metabolism of Carcinogens Be Targeted for Cancer Prevention?
Given the crucial role of carcinogen metabolism in cancer development, targeting these pathways offers a promising approach for cancer prevention. Strategies include:
Using inhibitors of specific cytochrome P450 enzymes to reduce the formation of reactive intermediates. Enhancing the activity of Phase II detoxifying enzymes through dietary components and supplements. Personalizing prevention strategies based on genetic profiling to identify individuals at higher risk due to variations in metabolic enzymes.
