Yes, non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play significant roles in gene regulation and cancer. miRNAs can bind to messenger RNAs (mRNAs) and prevent their translation into proteins, effectively silencing genes. Abnormal expression of miRNAs can disrupt normal cellular functions and contribute to cancer progression. Similarly, lncRNAs can interact with DNA, RNA, and proteins to regulate gene expression and chromatin structure, influencing tumorigenesis.