Can PARP Inhibitors be Combined with DNA Damaging Agents?
Yes, the combination of PARP inhibitors with DNA damaging agents is a promising therapeutic strategy. The rationale is that the inhibition of PARP will prevent the repair of the DNA damage induced by these agents, thereby enhancing their cytotoxic effects. This combination can potentially overcome resistance to single-agent therapies and improve treatment outcomes. However, such combinations also raise concerns about increased toxicity, so careful dosing and scheduling are essential.
