Yes, RNR is a promising target for cancer therapy. Several chemotherapeutic agents work by inhibiting RNR activity. For instance, hydroxyurea is a well-known RNR inhibitor that depletes dNTP pools, leading to the inhibition of DNA synthesis and induction of cell death in rapidly dividing cells. Gemcitabine, another chemotherapeutic agent, also targets RNR by incorporating into DNA and inhibiting its synthesis.
