Can Sickle Cell Anemia Increase the Risk of Cancer?
Yes, sickle cell anemia can increase the risk of cancer. The chronic hemolysis and subsequent release of free hemoglobin can create an oxidative environment conducive to DNA damage. Furthermore, the bone marrow's constant effort to replenish red blood cells can lead to a high turnover rate, increasing the likelihood of genetic mutations over time. This environment may predispose patients to developing malignancies, particularly in the blood and bone marrow.
