Can Targeting Nutrient Gradients Improve Cancer Therapy?
There is growing interest in developing therapies that specifically target the metabolic adaptations of cancer cells to nutrient gradients. Approaches such as anti-angiogenic therapy aim to normalize tumor vasculature, improving nutrient delivery and enhancing the effectiveness of conventional treatments. Additionally, targeting metabolic pathways unique to cancer cells, such as inhibiting glycolysis or glutaminolysis, can potentially exploit the vulnerabilities created by nutrient gradients, leading to more effective cancer therapies.
