Can the Tumor Microenvironment Influence Resistance?
Yes, the tumor microenvironment plays a crucial role in chemotherapy resistance. The microenvironment includes the surrounding blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix. These components can create a protective niche for cancer cells, making them less accessible to chemotherapy drugs. For instance, hypoxic conditions within the tumor can lead to the activation of survival pathways that promote resistance.
