Cathepsins are implicated in cancer due to their role in the degradation of the extracellular matrix (ECM), which can facilitate tumor invasion and metastasis. Elevated levels of certain cathepsins, such as cathepsin B, L, and S, have been observed in various types of cancers. These enzymes contribute to the cancerous behaviors of cells by enabling them to break through the ECM and spread to other parts of the body.
