In the context of cancer, cyclins are often found to be deregulated. This deregulation can lead to uncontrolled cell proliferation, a hallmark of cancer. Overexpression or amplification of specific cyclins, such as Cyclin D1, Cyclin E, and Cyclin A, has been observed in various types of cancers. These abnormalities can result from genetic mutations, epigenetic changes, or disruptions in cell signaling pathways.
