There are several strategies for depleting MDSCs, including:
1. Chemotherapy: Some chemotherapeutic agents, like gemcitabine, selectively target and deplete MDSCs. 2. Targeted Therapies: Agents such as tyrosine kinase inhibitors can also reduce MDSC levels. 3. Immune Checkpoint Inhibitors: Drugs like anti-PD-1 and anti-CTLA-4 antibodies can indirectly reduce MDSCs by activating the immune system. 4. Small Molecule Inhibitors: These inhibitors target specific pathways involved in MDSC recruitment and function. 5. Dietary Interventions: Certain dietary components, such as omega-3 fatty acids, have shown potential in reducing MDSC levels.
