Rho GTPases are regulated by three main types of proteins: - Guanine nucleotide exchange factors (GEFs): Activate Rho GTPases by facilitating the exchange of GDP for GTP. - GTPase-activating proteins (GAPs): Inactivate Rho GTPases by accelerating the hydrolysis of GTP to GDP. - Guanine nucleotide dissociation inhibitors (GDIs): Maintain Rho GTPases in an inactive state by preventing the dissociation of GDP.
