How Can Epigenetic Data Be Used in Cancer Treatment?
Epigenetic data can be leveraged in several ways for cancer treatment:
1. Biomarkers: Epigenetic modifications can serve as biomarkers for cancer diagnosis, prognosis, and response to treatment. For example, hypermethylation of the MGMT gene is used to predict the response to alkylating agents in glioblastoma.
2. Epigenetic Therapies: Drugs that target epigenetic modifications, such as DNA methyltransferase inhibitors (e.g., azacitidine) and histone deacetylase inhibitors (e.g., vorinostat), are being developed and tested in clinical trials.
3. Combination Therapies: Combining epigenetic therapies with traditional treatments like chemotherapy and immunotherapy can enhance their efficacy and overcome resistance.
