Given its role in maintaining protein homeostasis in cancer cells, ERAD can be targeted through various strategies: - Inhibitors: Small molecules that inhibit specific components of the ERAD pathway, such as [proteasome inhibitors], can disrupt the degradation of misfolded proteins, leading to increased ER stress and apoptosis in cancer cells. - Genetic Interventions: Techniques like [CRISPR-Cas9] can be used to knock out genes encoding key ERAD components, thereby impairing the pathway and inducing cell death in cancer cells.
