AChEIs work by binding to the active site of acetylcholinesterase, preventing the enzyme from breaking down acetylcholine. This results in increased levels of acetylcholine in the synapse, which can enhance cholinergic transmission. In the context of cancer, the mechanism is not entirely understood, but it is hypothesized that the increased cholinergic activity could interfere with cancer cell signaling pathways and inhibit tumor growth.
