How Do Alterations in Mitochondrial Ribosomes Contribute to Cancer Progression?
Alterations in mitoribosomes can lead to defective mitochondrial protein synthesis, impairing the mitochondria's ability to produce energy efficiently. This can induce a state of metabolic reprogramming, where cancer cells adapt to their energy needs by upregulating glycolysis. Additionally, defective mitoribosomes can trigger mitochondrial stress responses, leading to increased production of reactive oxygen species (ROS). Elevated ROS levels can cause DNA damage and promote mutations, further driving cancer progression.
