Metastasis, the spread of cancer cells from the primary tumor to distant organs, is a major cause of cancer-related mortality. CSCs are believed to play a pivotal role in this process. Their ability to self-renew and differentiate allows them to survive in circulation, colonize new sites, and form secondary tumors. The epithelial-to-mesenchymal transition (EMT) is a process that enhances the migratory and invasive properties of CSCs, facilitating metastasis.
