How Do Metabolic Pathways Contribute to Drug Resistance?
Altered metabolic pathways can contribute to drug resistance in cancer. For example, increased glycolysis and lactate production can create an acidic microenvironment that affects drug uptake and efficacy. Additionally, the activation of alternative metabolic pathways can provide survival advantages to cancer cells under therapeutic stress. Understanding these mechanisms can help in designing combination therapies that target both metabolic pathways and traditional oncogenic pathways.
