How do MMPs interact with other Proteases and Proteins in Cancer?
MMPs interact with other proteases, such as serine proteases and cysteine proteases, to coordinate the degradation of ECM components. They also interact with proteins such as tissue inhibitors of metalloproteinases (TIMPs), which regulate MMP activity. The balance between MMPs and TIMPs is crucial for maintaining ECM homeostasis, and its disruption can contribute to cancer progression.
