PRRs, such as Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs), can detect DAMPs released by stressed or dying cancer cells. These receptors can identify abnormal patterns in the cellular components of cancer cells, such as altered nuclear DNA, mitochondrial DNA, and other intracellular components. This recognition triggers an immune response aimed at targeting and eliminating the cancer cells.
