How Do RNA Modifying Enzymes Contribute to Cancer?
RNA modifications can significantly impact gene expression and protein synthesis, which are often dysregulated in cancer. Abnormal activity of RNA modifying enzymes can lead to uncontrolled cell growth, metastasis, and resistance to apoptosis. For example, overexpression of the enzyme METTL3, which catalyzes N6-methyladenosine (m6A) modification, has been linked to poor prognosis in several cancers.
