How do Tregs and FoxP3 contribute to tumor growth?
Tregs, through FoxP3, can suppress the activity of cytotoxic T lymphocytes (CTLs) and other immune cells that are capable of attacking tumor cells. This immunosuppressive environment allows tumors to evade immune detection and grow unchecked. High levels of Tregs in the tumor microenvironment are often associated with poor prognosis in several types of cancers, including breast, ovarian, and lung cancer.
