Direct inhibition works by directly binding to the target molecule and obstructing its function. This can be achieved using small molecule inhibitors, monoclonal antibodies, or other biologics that are designed to interfere with the biological activity of the target. For example, tyrosine kinase inhibitors (TKIs) block the activity of tyrosine kinases, which are enzymes that play a crucial role in signaling pathways that regulate cell division and survival.
