How Does DNA Replication Stress Contribute to Cancer?
In cancer cells, elevated replication stress is often observed due to increased proliferation rates and oncogene activation. This stress can lead to DNA damage, which, if not properly repaired, can cause mutations. These mutations may give rise to oncogenes or inactivate tumor suppressor genes, thereby promoting tumorigenesis. Furthermore, replication stress is known to induce chromosomal rearrangements and aneuploidy, which are common features in many cancers.
