The process involves the hybridization of target DNA or RNA sequences with complementary DNA probes. These probes are usually labeled with a marker that allows for the detection of the hybridized molecules. The technique can be broadly divided into two types: Hybrid Capture 1 (HC1) and Hybrid Capture 2 (HC2). HC1 is primarily used for research purposes, while HC2 is more commonly used in clinical diagnostics, such as screening for human papillomavirus (HPV).
