How Does Mechanical Failure Contribute to Cancer Progression?
The mechanical properties of cells and their surrounding matrix are critical for maintaining normal tissue function. In cancer, alterations can occur in the stiffness of the extracellular matrix and the cells. This can lead to disruptions in cell signaling pathways, promoting cancer cell proliferation, migration, and invasion. For instance, increased matrix stiffness has been linked to enhanced tumor growth and metastasis.
