PDK1 acts as a master regulator of several downstream kinases, including Protein Kinase B (AKT), which are pivotal in promoting cell proliferation and inhibiting apoptosis. Overexpression or hyperactivation of PDK1 can lead to uncontrolled cellular growth and survival, contributing to tumorigenesis. Additionally, mutations in the PI3K pathway, which often includes PDK1, are common in many types of cancer.
