The ABVD regimen functions by utilizing the unique mechanisms of its constituent drugs:
Adriamycin (Doxorubicin): This drug intercalates DNA strands, inhibiting the enzyme topoisomerase II, which is essential for DNA replication. Bleomycin: Bleomycin causes breaks in DNA strands, leading to cell death. Vinblastine: Vinblastine disrupts microtubule formation, preventing cell division. Dacarbazine: This drug alkylates DNA, resulting in cross-linking and mispairing of DNA, which triggers cell death.
